Paliperidone is a second generation antipsychotic agent, used in the treatment of schizophrenia. It is a hydrophobic drug which belongs to BCS class II and it has low bioavailability of about 28%. The present study was designed to improve the in-vitro dissolution properties of poorly soluble antipsychotic drug paliperidone by adopting the liquisolid technology. Liquisolids were prepared by powder solution technology using lactose as carrier, poly vinyl pyrolidone K25 as coating material, PEG 200, tween-80, propylene glycol as non-volatile solvents and sodium starch glycolate is used as a superdisintegrant. FTIR studies were carried out for all formulations. All prepared liquisolid compacts were subjected to weight variation, drug content uniformity, hardness, friability test, disintegration test and in-vitro dissolution tests. All the tested formulations showed higher drug dissolution than the pure drug. Optimized formulation LS8 containing tween-80 as solvent, lactose and PVP K25 in 10:1 ratio exhibited faster disintegration and desirable drug release of 99.15% in 45 min. Liquisolid technology is a promising method for solubility enhancement of paliperidone.
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